Will you be the first P16 Billion Powerball jackpot winner from the Philippines? STAT LINESLillard made 1 of 10 shots and scored six points in the first half, then made 8 of 12 shots and scored 25 points after the break.HAMMER TIMEHip hop legend MC Hammer attended the game and chatted with Westbrook for several minutes afterwards.QUOTABLEGeorge, on the vibe in the arena as Westbrook tried to set the triple-double record: “It just felt amazing. The energy was awesome.”UP NEXTPortland hosts Golden State on Wednesday.Oklahoma City plays at New Orleans on Thursday. View comments Don’t miss out on the latest news and information. James Harden runs 30-point streak to 30 as Rockets thump Mavs Westbrook broke a tie with Wilt Chamberlain, who had nine straight triple-doubles in 1968, by finishing with 21 points, 14 rebounds and 11 assists. Westbrook already was the only person to average a triple-double in consecutive seasons, and he set the single-season record for triple-doubles with 42 in 2016-17.He downplayed this record while still showing respect for Chamberlain.FEATURED STORIESSPORTSGolden State Warriors sign Lee to multiyear contract, bring back ChrissSPORTSCoronation night?SPORTSThirdy Ravena gets offers from Asia, Australian ball clubs“I just go play the game the right way,” he said. “It’s what I do. Go out and compete every night and leave it on the floor, and whatever happens, happens. I’m very, very blessed to be able to go out and play, and I don’t take it for granted.”Westbrook clinched the record on an assist to George for a 3-pointer with 3:52 remaining in the fourth quarter. Ginebra beats Meralco again to capture PBA Governors’ Cup title Gretchen Barretto’s daughter Dominique graduates magna cum laude from California college Carpio hits red carpet treatment for China Coast Guard PLAY LIST 02:14Carpio hits red carpet treatment for China Coast Guard02:56NCRPO pledges to donate P3.5 million to victims of Taal eruption00:56Heavy rain brings some relief in Australia02:37Calm moments allow Taal folks some respite03:23Negosyo sa Tagaytay City, bagsak sa pag-aalboroto ng Bulkang Taal01:13Christian Standhardinger wins PBA Best Player award Oklahoma City Thunder guard Russell Westbrook, left, and forward Paul George, right, celebrate late in the second half of an NBA basketball game against the Portland Trail Blazers in Oklahoma City, Monday, Feb. 11, 2019. (AP Photo/Sue Ogrocki)OKLAHOMA CITY— Chalk up another triple-double record for Russell Westbrook.Westbrook set an NBA record with his 10th straight triple-double, Paul George scored 47 points, and the Oklahoma City Thunder beat the Portland Trail Blazers 120-111 on Monday night.ADVERTISEMENT Ginebra beats Meralco again to capture PBA Governors’ Cup title The Thunder shot 56 percent in the first half to lead 68-49 at the break. George scored 21 points and Felton added 15.The Trail Blazers started the second half on a 7-0 run to make things interesting, and they trimmed Oklahoma City’s lead to 87-82 by the end of the third quarter.Westbrook had five assists heading into the fourth, and after a rest, he re-entered the game with 9:36 remaining. He got his first assist of the quarter with 6:54 left and was up to his ninth with 4:57 to play.Westbrook made a 3-pointer in the final minute that gave George his triple-double. Westbrook told George that he was one assist away.“Yeah, we talked about it right before that play,” George said. “We talked about it. I was clueless at that moment. But he told me the situation. So, it’s cool to be on the other end of the triple-double.”Westbrook figured he might as well get a different kind of assist.“It’s amazing to go out and compete,” he said, “to see your teammate, your brother, do amazing things, and you can be right on the side of him doing something special as well.”TIP-INSTrail Blazers: CJ McCollum was called for a technical in the second quarter. … McCollum shot 4 for 15. … Portland shot 33.3 percent in the first half.Thunder: Forward Jerami Grant (right ankle sprain) and guard Dennis Schroder (personal reasons) did not play. … George scored 17 points in the first quarter. … Burton hit a 3-pointer at the first-quarter buzzer. … Forward Patrick Patterson got his fourth start of the season in Grant’s place. “I thought he had it already,” George joked. “Usually, Russ has that by the first quarter. I didn’t know it was that close.”It was Westbrook’s 23rd triple-double of the season and the 127th of his career. Most important to the Thunder, the team has a 9-1 record during his triple-double run.“I do know the most important thing for him is to win,” Thunder coach Billy Donovan said. “That’s what he’s about. He wants to win. I think a lot of the things he does that he gets attention for in terms of the triple-doubles are things that impact winning for our team.”George had 12 rebounds and 10 assists for the third triple-double of his career. Rookie Deonte Burton had a career-high 18 points and Raymond Felton added a season-high 15 for the Thunder.Damian Lillard scored 31 points and Jake Layman added 17 for Portland.ADVERTISEMENT Tom Brady most dominant player in AFC championship history Japeth Aguilar wins 1st PBA Finals MVP award for Ginebra Nadine Lustre’s phone stolen in Brazil MOST READ Sports Related Videospowered by AdSparcRead Next Philippine Army to acquire MANPADS, self-propelled howitzers In fight vs corruption, Duterte now points to Ayala, MVP companies as ‘big fish’ LATEST STORIES
POMONA – Day 1 of Tony Mandella’s second NHRA season will begin especially early this morning. “I’ll wake up around 5:30,” the 21-year-old driver from Upland said Friday, “mainly because I won’t be able to sleep. First-race jitters.” His first name, that is. Tony’s father, Phil, was a fixture in the Super Stock division before reducing to a part-time schedule in the last decade. He now runs Phil Mandella Racing, which builds and fabricates dragsters, several of which will run this weekend. Tony’s uncle, Ronnie, was the family’s first NHRA driver and is in town this weekend to watch his nephew race for the first time in six years. Yet despite his lineage – having practically grown up on a racetrack – and already having a full NHRA season under his belt, it’s still not an easy sleep the night before Day 1. “It’s pretty important,” Tony said of this weekend’s race. “If you go far enough in the rounds, you could be in the points for the year. “Then you get your name out there, get a reputation for yourself and try to work your way up.” Mandella will roll out his 1966 Chevy Impala for three rounds of Stock class qualifying today at the NHRA Winternationals. Friday’s round was scratched after an early oil spill on the Auto Club Raceway track caused a long delay. And that leaves a lot of work ahead this weekend for Mandella, who, in his second season as one of the NHRA’s up-and-coming sportsman drivers, is looking to get his name out there. Last year, Mandella was happy just to finish among the top 40 (38th) in his rookie season. Unlike the majority of his competitors, he did so while taking a full college class schedule at Azusa Pacific University. This year Mandella isn’t backing off school at all. He was enrolled in 18 units last semester and will be for the upcoming term as well. And yet, if you ask him where he sees himself 10 years down the road, the answer is surprisingly definite for a 21-year-old with one foot in college and the other in a dragster. “I’m always going to be drag racing,” Mandella said. “I’ll never be able to get away from it.” A 2004 graduate of La Verne Lutheran High School, Mandella played baseball, football, soccer and track & field. Concurrently he followed his dad around the country to a geographically diverse list of NHRA tracks, getting quite an education on the road. “I knew I wanted to be racing,” he said. Mandella got started in the junior dragster circuit at 16 and over the years pitched in at PMR on the side. Finally debuting in the NHRA last season, he peaked at the season’s penultimate race, advancing to the semifinals in Las Vegas on Oct. 29. A week later at the season-ending event in Pomona, Mandella advanced to the third round of eliminations before bowing out. Not a bad way to end your first season, for sure. But as Mandella notes, “I haven’t won a race in this car yet. “That’s going to change this weekend.” 160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set!
0Shares0000German Football Association (DFB) president Reinhard Grindel (L) is congratulated by UEFA president Aleksander Ceferin after it was announced that Germany will host Euro 2024 © AFP / Fabrice COFFRININYON, Switzerland, Sep 27 – Germany on Thursday won the race to host the 2024 European Championship as UEFA backed a bid seen as safer than the rival Turkish proposal.UEFA President Aleksander Ceferin announced the winner following a campaign that saw politics and concerns over human rights in Turkey play a central role. “I’d like to thank the UEFA Executive for their incredible confidence and I feel the responsibility — we will do our utmost to live up to expectations,” said German Football Association (DFB) president Reinhard Grindel after the announcement.“We want to put on a huge football festival and show the world how hospitable we are,” said ex-Germany captain Philipp Lahm, who will head the organising committee.UEFA considered that the German bid already had everything in place to host a successful event — from stadiums to infrastructure and hotels.European football’s governing body has also said it wants to make as much money as possible from the 2024 tournament and Germany was considered the better financial bet.The win also offers a boost to German football after a disastrous 2018 World Cup, when the country failed to qualify for the last 16 — after winning the tournament in 2014.German foreign minister Heiko Maas said the 2024 tournament “will be an opportunity to show what we stand for in Germany: openness to the world and tolerance, freedom and respect.“Together, we have to make the European Championship a tournament for all Europeans,” he added in a statement.Turkey meanwhile had been desperate to host its first ever major sporting event but its bid was weakened by concerns over its faltering economy, lacking transport network and, perhaps most importantly, human rights.Turkish President Recep Tayyip Erdogan loomed large over the campaign and Thursday’s defeat may be seen in part as a personal rebuke.His government’s unprecedented crackdown, including thousands of arrests, following a failed 2016 coup has raised worldwide concern.That unease was shared by UEFA, which noted in its evaluation report that the Turkish bid’s “lack of action plan in the area of human rights is a matter of concern.”0Shares0000(Visited 1 times, 1 visits today)
Aodh Ruadh GAA News: FootballAodh Ruadh saw off a dogged Downings outfit to climb to third place in the division three table, just two points behind the early pace-setters Milford. Aodh Ruadh remain unbeaten at Father Tierney Park this season. The young guns, Shane McGrath and Nathan Boyle, were among Ballyshannon’s best performers on the day Johnny Gethins, Conor Patton and Michael Dolan all put in eye-catching shifts while David Dolan made a welcome return to senior football, helping steady the ship in the closing stages.Man of the match was Diarmaid McInerney who contributed well from open play and showed great polish from placed ball. We have a full match report and pictures from the game up on aodhruadh.org. The reserves enjoyed less success against the visitors, coming out on the wrong end of a six goal goalfest, 2-5 to 3-8 the scoreline in favour of Downings. Aodh Ruadh played the first half with the wind at their backs and James Kelly and Michael McNeely shot two goals in that period to help the homesters to a 2-3 to 1-3 half-time lead. However Downings got off to a great start in the second half and despite a third goal from Jamie McDonald Ballyshannon simply couldn’t reel the Rosguill peninsula side in. We have a full match report and pictures from the game up on aodhruadh.org.This weekend Aodh Ruadh are at home again with Red Hugh’s the visitors. The reserve games throws in at 4.30pm, and is followed by the seniors at 6pm.The under 16s are in action this Wednesday 22nd April at 6.30pm when they travel to Tir Chonaill Park to take on Four Masters.Under 14 training this week is at 6.15pm on Wednesday. Election of our captain for 2015 will take place at this session. The team’s first league fixture is this Saturday when they travel to take on Dungloe. Throw-in time will be 12 noon. As many parents as possible should come along to ensure we have lifts for all the players. Assemble at the park for 9.30am, departing at 9.45am.Under 10 and under 12 training continues on Wednesdays from 6pm to 7pm and Mondays from 6pm to 7pm.Training continues this Friday for the under 8s and under 6s from 6.30pm to 7.30pm in Páirc Aoidh Ruaidh. Any new faces who want to join in the craic are more than welcome.Hurling Aodh Ruadh made the trip to Garvaghey in Tyrone for their fixture against Louth outfit Saint Fechin’s in the Táin League on Sunday last. This game epitomised the phrase, ‘a game of two halves.’ The tie was very evenly balanced throughout the first half with the Ballyshannon men squandering a lot of chances to capitalise on their 3-4 to 1-4 half time cushion. Saint Fechin’s slowly chipped away and with Aodh Ruadh only managing two points in the second half, they relinquished their lead and eventually the game on a score line of 3-6 to 2-11. Aodh Ruadh are back in action next Sunday against Louth’s Knockbridge in Garvaghey at 1pm.On Thursday last the minors faced a strong Saint Eunan’s in Father Tierney Park. We’ve a very small squad this year and again this week we just had the bare 15, but what a performance the lads put in. Saint Eunan’s got off to a great start and led 1-2 to no score after about 10 minutes. The lads slowly clawed themselves back into the game and began to get more belief in themselves. They finished the first half strongly and went into the break two points down 1-5 to 0-6 in favour of the Letterkenny men. The lads put in a great second half, putting in huge work-rate and began to dominate the more the game went on. All 15 played their part and the workload was evenly shared and it was encouraging to see some players stepping up and taking responsibility. At the end of a great match between two very committed teams Aodh Ruadh won out 1-13 to 1-8. The lads deserve great credit for winning their opening four games, we haven’t had a sub in any of the games and once again the effort the boys are putting in must be admired. They play Strabane this Thursday in Father Tierney Park, throw in 7pm. All support for this hard working team is most welcome.On the same night the under 14s played Four Masters in Donegal Town. A number of injuries seemed to affect the team and they never got going in the first half and Four Masters were allowed dominate. The second half saw the boys put in a much improved performance, but unfortunately the damage was done in the first 30. Four Masters were convincing winners on a 5-12 to 2-2 score line. The most disappointing aspect to this game was the lack of effort and work rate shown by some of the team, an area that will have to be improved on.On Sunday the under 14s were in action again this time they travelled to Killygordon to take on Setanta. They got off to a bad start and Setanta had 2-1 on the board before our lads got their first score. Thankfully the work rate and effort was much improved from the previous game and the lads thundered back into the encounter. Tt was a great game between two teams who gave it their all. There was nothing between the teams in the second half and when the final whistle was blown the game was level at 3-3 apiece, a fair result. The lads showed a far better work ethic in this game and hopefully that will continue for the rest of the league campaign. After the game Donegal star Danny Cullen spoke to the lads and gave them some very good words of advice. They face a difficult task this Thursday when they entertain table toppers Saint Eunan’s. We had great numbers of under 8s, under 10s and under 12s at training on Sunday, all worked very hard and are coming along well, hope to see them all again this Sunday at 12 noon.LadiesWell done to Sarah Patton and the Donegal ladies who have topped division 2 with victory over Cavan at the weekend and are still undefeated in the league.The ladies training schedule for the coming week is as follows.Under 8 (born 2007/2008) Training Mondays 6-7pm in the Mercy HallUnder 10 (born 2005/2006) Training Mondays 6-7pm in the Mercy HallUnder 12 (born 2003/2004) Training Mondays 6-7pm at the ParkUnder 14 Training Tuesdays and Thursdays 6-7pmUnder 16, minor and senior training is on Tuesdays and Thursdays 7.30-8.30pmSkydive rescheduled for this SaturdayFor safety reasons the eagerly awaited Aodh Ruadh, Ballyshannon Come Dive With Me Skydive due to take place last Saturday 18th April did not go ahead. Although Saturday was a fabulous day at ground level the gusty conditions at 10,000 feet were a very different matter and the operators at Abbeyshrule Airport in Longford could not give the go-ahead due to the wind speeds. There was fantastic support for the eleven divers at the airport, more than 30 family and friends had travelled to offer their support and encouragement to the jumpers. The Skydive has been rescheduled for this coming Saturday 25th April when hopefully weather conditions will be more favourable. If you wish to sponsor any of the Skydivers contact Tom Daly on 0872390410, Conal Gallagher at 0862112812, David McLoone on 0877760172, or any of the Aodh Ruadh Park/Development Committee, or any of the Skydive Team. We have a picture of the jumpers down in Longford on aodhruadh.org.Operation BallyshannonApril is National Spring Clean month and following on from previous year’s success, Operation Ballyshannon will be held on Saturday 25th April in conjunction with the on-going work of the Ballyshannon Regeneration Group. This one-day spring clean blitz will focus in on some problem areas and improve the physical appearance of the town. Everything from painting, power-washing, weeding, strimming, planting flowers and litter collection will be organised on the day. We are asking local builders, painters, carpenters, labourers, sporting and community groups, business people, local schools and the general public to come out and give this one day to your town and instil some civic pride in the community. Work will commence at 10am. Meeting point on Saturday morning at 9.30am will be Ballyshannon Public Service Centre Offices, Abbeyview. Gloves, bags, high visibility jackets, etc. will be supplied. Please bring along your own tools if possible. Refreshments will be served afterwards. Ballyshannon is set in an idyllic setting which looks out over the estuary and has panoramic views of nearby mountains – be proud of the town you live in, this is your chance, your town needs you, so please give it this one day. Taking part will really make a difference, so why not come out for a while on Saturday morning to help in some way with this clean up. We promise you’ll enjoy it!God of CarnageBallyshannon Drama Society’s production of Yasmina Reza’s God Of Carnage will stage its last two shows before the All-Ireland finals on Monday 27th April and Tuesday 28th April. Shows commence 8.30pm nightly and tickets are available priced €12 or €10 on concession. The play is directed by Anne McHugh and features the acting talents of Trisha Keane, Rachel O’Connor, Richard Hurst and Tony Liston.Dancing in the Rock HallCéilí, Old Time, Barn Dance and Set Dancing in Dorrian’s Imperial Hotel Ballyshannon Saturday 25th April at 9pm. Music by the Assaroe Céilí Band with the proceeds in aid of Baby Rory’s Will To Walk. Set dancing music by Owen Maguire and Catherine Mulligan. Admission is €8 with supper served.Club kitWe now have official club shorts available to order. They are O’Neill’s, so top quality kit. Kids sizes (24 and 26) cost €18, while adult sizes (28, 30, 32, 34, 36 and 38) cost €22. We’ll have samples available and images on aodhruadh.org. Contact Chris Kelly on 0868813553 to place your order. Our navy blue soft shell jackets are also back on sale. We now have three youth sizes available. Ages 7-8 priced €40; ages 9-10 priced €40; and ages 11-12 priced €45. All jackets will have the Aodh Ruadh and GAA crests, plus the child’s initials on the sleeve. We are also able to order Ladies soft shell jackets with pink Aodh Ruadh crest and GAA logo. We are also selling adult jackets. You can check out samples of the shorts and jacket on aodhruadh.org. For further details call Chris on 0868813553.Abbey Centre BingoMichael Feely of Kinlough won the €400 jackpot. The April Big Bingo is this Friday at 9pm in the Abbey Centre with a massive prize fund of €2,700, including the €1,000 jackpot. Books priced at €15 for a full book, or half books for €8, or get the book and a half special for €20. See you there.Aodh Ruadh LottoThere was no winner of last week’s Aodh Ruadh Lotto jackpot of €5,300. The winning numbers drawn were 3, 4, 6, 13, 15 and 16. In the lucky dip €20 went to: Ciara Boyle; Anthony Gallagher, c/o Pearse O’Neill’s; Maureen Keenaghan, Coolcholly; Catherine Gethins, Finner; Brian Drummond, Abbeylands; Monica and Pat Quinn, Benildus Avenue. Next draw in Pat’s Bar with a Jackpot of €5,400 on Sunday at 8.30pm.The lotto team for McCosker’s Centra this Saturday is: JUVENILE HURLERS.You can receive the club notes by e-mail every Tuesday morning. To subscribe, enter your details on the website, www.aodhruadh.org, or e-mail your request to email@example.com.GAA NEWS: AODH RUADH EARN HARD FOUGHT VICTORY OVER DOWNINGS TO GO THIRD IN DIVISION THREE was last modified: April 21st, 2015 by Mark ForkerShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)Tags:Aodh RuadhGAANoticesSport
A WOMAN accused of failing to provide a specimen of breath to a Garda who suspected her of drinking and driving has had the case dismissed by a judge.Judge Paul Kelly, sitting in Carndonagh District Court, made the decision after hearing evidence against the female motorist.The case was contested by solicitor Frank Dorrian on behalf of his client who was involved in a road traffic accident near Malin in 2011. A first aider at the scene said the woman was initially compliant but was clearly upset and later refused his further offers of help.The woman also later declined help from ambulance personnel, said Mr Dorrian, who argued she had suffered some sort of head injury, was upset and disorientated.A Garda, under cross-examination from Mr Dorrian, admitted that he had formed the opinion that the motorist had been drinking after observing her behaviour.He then asked her to give a roadside breath sample which she refused.The Garda agreed that the woman did later agree to giving a breath test at a Garda station.However the prosecution charged the driver with failing to give the first breath test.Mr Dorrian argued that under road traffic legislation that the Garda could not use two ways to reach a belief that someone had been drinking and driving.In this case the Garda said he had formed the opinion on observation; and then proceeded to attempt to carry out a roadside breath test.The Garda could not, said Mr Dorrian, use both methods to form an opinion before taking the woman to the Garda station.Judge Paul Kelly said there were “several frailties” in the case and dismissed the charge.WOMAN CLEARED ON DRINK-DRIVING CHARGE AFTER ANOTHER LEGAL ARGUMENT was last modified: March 2nd, 2014 by John2Share this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:CarndonaghDistrict Courtdrink drivingMalin
Wayne Norton, the former University of Georgia head coach, is set to join some of the most accomplished coaches in track and field history next week as he is inducted into the Drake Relays Coaches Hall of Fame.As a coach of 37 Relays titles, there is no doubt of Wayne Norton’s love for the Relays and the Drake Relays Hall of Fame is honoring Norton for his service and commitment to the Relays and track and field. As a former collegiate athlete at Howard, Norton’s familiarity with the sport helped guide his teams to success. During his tenure, Georgia athletes won 25 individual national titles and earned All-America honors nearly 200 times. Norton’s athletes also won 61 SEC championships. Norton began his coaching career as a graduate assistant at Indiana University, where he earned his master’s degree in journalism, and served as an assistant at Northern Arizona before joining the Georgia staff as an assistant in 1990. From 2000-2015, Norton took over as head coach for both track and field and cross-country programs. The Drake Relays witnessed Norton’s athletes dominating the field on the Blue Oval. His men’s 400-meter hurdlers won four years in a row from 2006-2009 and his team won the men’s sprint medley three-straight years from 2012-2014. Norton has coached 30 individual Relays Champions and seven relay teams that took top honors. Print Friendly Version In those 15 years, Norton was a key component of Georgia’s many titles. His teams posted 29 top-20 finishes in national meets, including a third-place finish for the women at the 2014 NCAA Indoor Championships. His women’s teams also finished fifth in each of the last two NCAA outdoor meets and the men’s squad placed sixth in 2014.
A veteran origin-of-life researcher died last October: Leslie E. Orgel of the Salk Institute for Biological Studies. Orgel had co-authored Origins of Life on the Earth (1973) with Stanley Miller, the man whose spark-discharge experiment launched the modern origin-of-life craze in the 1950s (05/02/2003). Orgel worked in the field for decades and was familiar with all the different approaches.Apparently Orgel was working on an essay when he died. Gerald Joyce [Scripps Institute], who wrote a eulogy to Orgel in Nature last November (11/29/2007) submitted Orgel’s manuscript to PLoS Biology. It was published posthumously this week on January 22. Origin-of-life [OOL] researchers will not find much encouragement in Orgel’s last scientific will and testament. It bears careful reading, however, coming from someone who spent a lifetime working on and thinking about chemical evolution.The essay is entitled, “The Implausibility of Metabolic Cycles on the Prebiotic Earth.” The caption states, “In this essay, the final contribution of his scientific career, Leslie Orgel explores the severe difficulties that arise when these proposals are scrutinized from the standpoint of chemical plausibility.”To understand his critique, the reader should be aware that OOL research bifurcated into two disparate approaches in the 1990s. The “genetic” party, endorsed by Stanley Miller, Leslie Orgel, Jeffrey Bada (06/14/2002), Steven Benner (11/05/2004) and others, looks for prebiotic macromolecules able to carry genetic information: DNA, RNA, PNA (12/17/2005), TNA and other candidates. The newer “metabolic” party is less ambitious than to expect such complex polymers to arise naturally. They propose that self-sustaining cycles of simpler compounds might arise, to be “co-opted” later by information-storing RNA and DNA. Champions of this approach have included Gunter Wachterschauser, Michael Russell (12/03/2004), Harold Morowitz (03/23/2005), Stuart Kauffman (05/09/2006), and Robert Shapiro (02/15/2007). Robert Hazen gave it good press in the Teaching Company lecture series Origins of Life while comparing and contrasting both schools of thought and describing them as somewhat spirited and adamant rivals.While Orgel might be expected to be partial to the genetic school, his final criticisms of the field are broad enough to raise serious concerns about the ability of natural processes to produce life at all by any method. Combining this essay with Shapiro’s devastating critique of genetic approaches last year (q.v., 02/15/2007), it seems that both approaches, like warriors in close combat, have both given and received mortal wounds, falling down together.Orgel was not entirely dismissive of the metabolic approach on theoretical grounds. Indeed, he said, “If complex cycles analogous to metabolic cycles could have operated on the primitive Earth, before the appearance of enzymes or other informational polymers, many of the obstacles to the construction of a plausible scenario for the origin of life would disappear.” No obstinacy here; he would welcome such a discovery. It’s the implausibility of metabolic scenarios that, to him, render them useless in the real world. Scenarios cannot be merely clever and imaginative. They have to obey the laws of chemistry. They need to be experimentally demonstrable.Orgel’s essay is open for public reading. He stated, “The main purpose of this Essay is to examine the plausibility of these and some related hypothetical nonenzymatic cycles. Could prebiotic molecules and catalysts plausibly have the attributes that must be assigned to them in order to make the self-organization of the cycles possible?” Those without an organic chemistry background can wade through the jargon and decipher his main criticisms:Could is not good enough: “It must be recognized that assessment of the feasibility of any particular proposed prebiotic cycle must depend on arguments about chemical plausibility, rather than on a decision about logical possibility.” To claim a chemical reaction is possible does not mean it will ever happen. What are the specific reactants? How efficient are they? Researchers must present ideas that are chemically plausible, not just possible.Paper is not good enough: “It is a catalytic cycle in which a complicated sequence of enzymatic reactions is used to bring about indirectly a reaction that looks simple on paper, but is not easily achieved in practice.” A researcher needs to think about chemical cofactors required, and the possibility of damaging cross-reactions, for instance, or whether reactions in a cycle are likely to proceed in a realistic time frame.Time is not enough: A metabolic cycle on the primitive earth may have had eons longer to work than a chemist in a lab. “However, the identification of a cycle of plausible prebiotic reactions is a necessary but not a sufficient step toward the formulation of a plausible self-organizing prebiotic cycle.”Where are the exits? Every step in a metabolic cycle needs to be efficient enough to keep the whole cycle going. “The cycle could not survive if side reactions funneled off more than half of the cycle components irreversibly, because then the concentration of the cycle components would decline exponentially to zero.”Weakest link breaks the chain: A researcher might be able to propose that each step in a metabolic cycle, say the 11 steps in the reverse citric acid cycle, is plausible in a prebiotic environment. “However, the reactions are not independent because each reaction is pulled toward completion by the use of its product as the input for the subsequent reaction of the cycle.”Don’t forget thermodynamics: Because reactions are reversible, it is likely the input of a step will be depleted. “Whatever the original input, one would finish with an equilibrium mixture, the composition of which is determined by thermodynamics.” Equilibrium means you are at a standstill and nothing more will happen.Not all reactions are created equal: Orgel lists seven reactions in the reverse citric acid cycle (one popular scenario for a self-organizing metabolic scenario) that are completely different. “The reverse citric acid cycle involves a number of fundamentally different kinds of chemical transformations,” he said; “At the very least, six different catalytic activities would have been needed to complete the reverse citric acid cycle.” What would this require: six different environments on the early earth? This “could be argued, but with questionable plausibility,” he remarked.Beware of thieves: Damaging side reactions are often more likely to occur than the desired ones. Orgel gives examples, such as difficult carboxylation reactions. “This reaction would move material irreversibly out of the cycle, so one must postulate a specific catalyst that discriminates between succinic and malic acid.”Inspectors required: Biological enzymes in living cells are experts at discriminating between similar substrates. The same cannot be assumed in a prebiotic environment: “One needs, therefore, to postulate highly specific catalysts for these reactions. It is likely that such catalysts could be constructed by a skilled synthetic chemist, but questionable that they could be found among naturally occurring minerals or prebiotic organic molecules.”Minerals are not enough: Clay surfaces and other substrates have been popular ingredients in metabolic cycle scenarios. The necessary reactions might occur on these natural lab tables, they say. Orgel discusses two leading scenarios. “While the details of the two proposals are different, the difficulty of achieving all of the required reactions while avoiding all of the likely side reactions seems at least as formidable” in both of them.Hand-waving is not enough: Orgel criticizes a recent proposal by Wachtershauser that describes self-organization by “metabolic reproduction, evolution, and inheritance by ligand feedback.” Suggestive words. “Unfortunately he never explains, even in outline, how this mechanism could lead to the synthesis of the aminoacyl-nucleotide conjugates that seem to be an essential feature of the proposal.”One example is not enough: “The only autocatalytic cycle that has been demonstrated experimentally is that involved in the formose reaction—the polymerization of formaldehyde to give a notoriously complex mixture of products, including ribose, the organic component of the backbone of RNA.” Well, this must be the path to explore! Indeed, researchers have explored this path since it was discovered in the 19th century. Is it the holy grail? Not exactly; the mix must be seeded with certain impurities to get started, and “Despite some successes, it is still not possible to channel the formose reaction in such a way as to produce ribose in substantial yield.”Ribose, of course, is one of the most difficult essential parts of RNA to imagine forming on the prebiotic earth – especially in the presence of water (see Benner, 11/05/2004). The proposed hopeful cycles, unfortunately, produce a host of other unhelpful reaction products.Simple is not enough: Orgel begins a section on “Cycles and the Evolution of Complexity.” Assume a cycle begins. That does not mean that complexity will evolve. “A cycle … does not seem capable of evolving in any interesting way without becoming more complex.” The scenarios that suggest a substantial amount of “information content” will emerge from a simple cycle, with genetic macromolecules coming in late to add stability, are little more than “intuitions” – not schemes that can be examined critically.Variation is not enough: Suggesting that a change in temperature or concentration is a form of evolution is a play on words. For instance, “one could not usefully claim that the dependence of the rate of a reaction such as ester hydrolysis on reaction conditions is a form of evolution.” At some point you have to add complexity to the picture. “The evolution of any substantial additional complexity of a cycle, therefore, must depend on the appending of further reaction sequences to those present in the core cycle.”The law of diminishing returns: “Given the difficulty of finding an ensemble of catalysts that are sufficiently specific to enable the original cycle, it is hard to see how one could hope to find an ensemble capable of enabling two or more.” The further the scenario gets from the original simple cycle, the more the problems arise. Orgel has heard many proposals in his career. None of them “explains how a complex interconnected family of cycles capable of evolution could arise or why it should be stable.”Orgel spent several paragraphs dismantling Kauffman’s mathematical proposal for a peptide cycle, which is interesting to read for those with an appetite for details.2 Even more interesting are some off-the-cuff remarks he made that, like an overheard microphone in wartime, reveal weaknesses to the enemy:By faith: The discovery of a feasible, evolvable cycle would be a real breakthrough, but…What is essential, therefore, is a reasonably detailed description, hopefully supported by experimental evidence, of how an evolvable family of cycles might operate. The scheme should not make unreasonable demands on the efficiency and specificity of the various external and internally generated catalysts that are supposed to be involved. Without such a description, acceptance of the possibility of complex nonenzymatic cyclic organizations that are capable of evolution can only be based on faith, a notoriously dangerous route to scientific progress.By intelligent design: You can get fantastic experimental results if you add design to the equation:Ghadiri and his coworkers have demonstrated experimentally that peptide cycles of the type envisaged in Kauffman’s theory are possible. They first showed that peptides of length 32 that have been carefully designed to self-associate to form stable coiled-coils will facilitate the ligation of their N-terminal and C-terminal subsequences. This shows that the self-replication of peptides is possible. In later work they demonstrated the self-organization of networks of ligation reactions when more than two carefully designed input peptides are used. These findings, however, cannot support Kauffman’s theory unless the prebiotic synthesis of the specific 15mer and 17mer input peptides from monomeric amino acids can be explained. Otherwise, Ghadiri’s experiments illustrate “intelligent design” of input peptides, not spontaneous self-organization of polymerizing amino acids.Those words must surely sting in the ears of researchers trying to avoid the D word design. He presses the point: can these long chains necessary for autocatalytic cycles form spontaneously? In several paragraphs, he explains why not. The short answer invokes words that sound like Dembski’s criterion of specified complexity for design: “Clearly, self-organization requires catalysis that is not only sufficiently efficient but also sufficiently sequence-specific.”Let us bow our heads; No worship leader, Orgel pauses to marvel at how life does what it does:The catalytic properties of enzymes are remarkable. They not only accelerate reaction rates by many orders of magnitude, but they also discriminate between potential substrates that differ very slightly in structure. Would one expect similar discrimination in the catalytic potential of peptides of length ten or less? The answer is clearly “no,” and it is this conclusion that ultimately undermines the peptide cycle theory.”For a few more paragraphs, Orgel entertained various attempts to rescue Kauffman’s theory. Alas; “Even if such systems exist, their relevance to the origin of life is unclear,” he said mercifully. “It is unlikely, therefore, that Kauffman’s theory describes any system relevant to the origin of life.”In the conclusion of the essay, Orgel laid down the rules that all origin-of-life researchers must obey: in a phrase, get real. “In view of the importance of the topic, it is essential to subject metabolist proposals to the same kind of detailed examination and criticism that has rightly been applied to genetic theories.” (Here he referred to critiques by Shapiro; cf. 02/15/2007). At least the genetic theorists, like himself, have a “substantial body of experimental work” in their resumes. Orgel let the storytellers have it between the eyes:Almost all proposals of hypothetical metabolic cycles have recognized that each of the steps involved must occur rapidly enough for the cycle to be useful in the time available for its operation. It is always assumed that this condition is met, but in no case have persuasive supporting arguments been presented. Why should one believe that an ensemble of minerals that are capable of catalyzing each of the many steps of the reverse citric acid cycle was present anywhere on the primitive Earth, or that the cycle mysteriously organized itself topographically on a metal sulfide surface? The lack of a supporting background in chemistry is even more evident in proposals that metabolic cycles can evolve to “life-like” complexity. The most serious challenge to proponents of metabolic cycle theories—the problems presented by the lack of specificity of most nonenzymatic catalysts—has, in general, not been appreciated. If it has, it has been ignored. Theories of the origin of life based on metabolic cycles cannot be justified by the inadequacy of competing theories: they must stand on their own.Orgel tried to soften this blow with suggestions that plausible cycles might some day be discovered, for instance around hydrothermal events, and these deserve further investigation. “It is important to realize,” however, “that recognition of the possible importance of prebiotic syntheses that could occur hydrothermally does not necessitate a belief in their ability to self-organize.”…scenarios that are dependent on “if pigs could fly” hypothetical chemistry are unlikely to help.In the final paragraph, the final words of his final essay, he generalized to all kinds of origin-of-life theories. You need pure building blocks to get polymers that might replicate themselves. You need to sift the good from the bad in the complex mixtures that result from experiments. “No solution of the origin-of-life problem will be possible until the gap between the two kinds of chemistry is closed.” Then, he uttered his last scientific writing with the most stinging words of all, aimed at the whole OOL community:Simplification of product mixtures through the self-organization of organic reaction sequences, whether cyclic or not, would help enormously, as would the discovery of very simple replicating polymers. However, solutions offered by supporters of geneticist or metabolist scenarios that are dependent on “if pigs could fly” hypothetical chemistry are unlikely to help.Rest in peace, Dr. Orgel.1. Leslie E. Orgel, “The Implausibility of Metabolic Cycles on the Prebiotic Earth,” Public Library of Science: Biology, 6(1): e18, Jan 22, 2008, doi:10.1371/journal.pbio.0060018.2. Kauffman’s model depends on peptides growing to a certain length that can autocatalyze one another. Orgel shows additional factors that would be required, reducing the plausibility of his hypothesis, which is more mathematical than experimental to begin with. Kauffman misunderstands the thermodynamics of peptide bond formation. He thinks amino acids will be plentiful and will spontaneously form long polypeptides, Orgel complains, “In practice, this would not happen.” In fact, the need for coupling agents becomes a problem for all origin-of-life theories that depend on the formation of polypeptides or polynucleotides. The problem “could only be avoided by proposing a series of monomers, such as aminoaldehydes, that polymerize spontaneously, but the difficulty of finding a prebiotic synthesis of suitable monomers then becomes severe.”Ouch! Or should we shout, Amen! What a way to go. No more spark-discharging simple gases for him. Orgel has just tased everyone in the OOL community with shocks of realism. Does it get any better than this?We spent a lot of time on this entry because of its significance. Evolution’s theory of the origin of life is the fulcrum on which the entire evolutionary worldview rests, like an inverted pyramid at the tipping point. The news media, and children’s textbooks, make it all look so easy. NASA repeatedly insinuates that the mere presence of water on some planet or moon means that life can’t be far behind. For over 50 years now, textbooks have been decorated with Miller’s spark-discharge experiment, that useful lie, that icon of the Darwin Party propaganda machine (05/02/2003). The propaganda has deceived the public into thinking scientists have essentially solved the puzzle of the origin of life, and God is out of business.Orgel has been in the thick of actual OOL research and, thank God, did not lose his scientific realism completely like so many of the others have. Practically on his deathbed he has preached a final hellfire sermon against researchers who substitute imagination for reality, faith for experimentation. He reprimated those who unscrupulously insert that foreign, despised, prohibited ingredient into their equations: intelligent design! You may go speculate about flying pigs, Orgel says, but don’t claim that by doing so you are doing science, or helping the evolution movement.Read this article, then read Shapiro’s critique of the genetics-first approach (02/15/2007). Here you have two champions both collapsing in the ring with fatal wounds. Creationists and Intelligent Design debaters need do nothing but show the tape. The evolution advocates have falsified each other, the flying pig circus tent has collapsed, and the pyramid has tipped toward intelligent design, never to point toward evolution again.Thanks for hanging in there with this long entry. We just thought our readers would like to know what the silly TV shows and kiddie books aren’t telling you. As Porky (the flying) Pig always ended his Looney Tunes, “Th-Th-Th-That’s all, folks!” Cartoons are over. Get off the couch, go outside, and have a great day in the real world – the world of Creation.(Visited 284 times, 1 visits today)FacebookTwitterPinterestSave分享0
23 May 2014Tennis South Africa (TSA) will launch a new monthly Internet-based programme next week that will feature some of the leading names in the sport.Former players Robbie Koenig, currently a world-renowned television commentator, Jeff Coetzee, who is coach to the Colombian Davis Cup team, and Michael de Jongh, the former coach of Amanda Coetzer and Mary Pierce, will guide viewers through the latest news and behind-the scenes intrigue of the various tennis tours.StreamingThe programme will be shown via streaming with the first show going out on Tuesday, 27 May, at 19:00.Viewers will be able to connect through the TSA website (www.tennissa.co.za) by clicking on the “Game, Set and Match” icon.The programme will run for about 45 minutes. Those who miss the live streaming will be able to download it from the “Video On Demand” section in the Archive.AnchorIt will be anchored by De Jongh, who will be joined by Mike Dunk, who will conduct many of the interviews.As far as the international scene is concerned, Robbie Koenig will be doing an ATP Tour wrap, while Jeff Coetzee will be conducting behind-the-scenes interviews with players to learn about their personal lives, and how they prepare for matches and major tournaments.ContentThe programme will also encompass coaching tips, discussions on the rules, product, the TSA Reward Card, wheelchair tennis, schools news, club news, in-studio debates, nutrition, TSA results updates and highlights from local tournaments.Streamit 360 is handling the portal and production for TSA, with TSA owning the streaming rights.SAinfo reporter
What it Takes to Build a Highly Secure FinTech … markhachman Tags:#Microsoft#microsoft surface#tablet Why IoT Apps are Eating Device Interfaces Related Posts So what did Forrester’s report conclude?1.) Apple will win the next-gen smartphone war. Today, 92% of desktop PC users run Windows, 87% of notebook users do the same, while Apple powers 58% of the tablets. Android edges Apple in smartphone use, 37% to 34%. But 33% of workers want their next phone to be an iPhone; 22% want an Android phone, and 10% want a Windows phone. Some 7% own a BlackBerry, and apparently those same 7% want another.2.)Windows tablet demand tops Apple. Easily the biggest surprise of the report. Of those IT workers polled, only 2% own a Windows tablet. But 32% want one. That tops Apple, with just 26% of those polled wanting an iPad and 12% hoping for another Android tablet.“For CIOs, there are three mandates that arise from this data: 1.) Apple and Android will be major suppliers to the enterprise. 2.) Microsoft has a fighting chance in tablets. 3.) The workplace of the future is multiplatform,” Forrester’s report claims.3.)More workers are bringing their own devices to work, and more are paying for them, too. Forrester claims that we haven’t yet hit what it calls “peak BYOD.” But aleady more than a third of workers who bring smartphones and laptops into the office picked what they wanted, themselves, the report found. About 12% of workers bought (or were forced to buy) their notebooks themselves, and 18% more (or 129 million workers) bought their own phones.In total, 36% of the knowledge-based workforce is ready and willing to pay for the computer they want, the report found. “We read that result as code for “I’d like a MacBook or iMac, please,” Forrester said.The report also noted that more and more employees don’t mind having their devices managed by their employer. If a worker loses a cell phone, for example, an IT shop that activates a “kill switch” will wipe the user’s device. Workers these days are finding that blocking a thief’s access to their personal data is as valuable as blocking access to corporate data, the report concluded.With more and more workers using multiple devices – desktop, notebook, phone and tablet – and IT shops allowing these devices onto the corporate network, Microsoft may be right – the world may indeed want Windows. Microsoft Q&A With Tami RellerThat’s all certainly good news for Microsoft, but Windows 8’s future remains far from certain. In a “question and answer” session with Windows marketing officer Tami Reller published Monday, Reller stuck to the party line about how “more than 60 million licenses” had been sold for Windows 8, “on par with the record-setting pace we saw with Windows 7.”“With Windows 8, we’ve built an OS that scales across the entire segment: tablets, to PCs to everything PCs can become, with one consistent scalable experience,” Reller said. “Windows 8 is a big, ambitious change and as I said, we’re only just getting started.”Nothing has changed here. Reller is repeating the same points that she has been hammering for weeks now. Yes, Microsoft delivered solid financial results for the most recent quarter. But persistent questions about Windows 8 demand have lingered, and Forrester’s report may have answered some of them. Role of Mobile App Analytics In-App Engagement Good news for Microsoft: 200 million information workers want Windows tablets, a report from Forrester claimed Monday, quite a few more than the 900,000 Surface RT tablets that IDC estimated have already been sold into the channel.If Forrester’s numbers truly reflect reality, they indicate a huge pent-up demand for the Surface Pro, which goes on sale this month. The report concludes that both Apple and Microsoft will go at each other’s throats to win knowledge workers to their respective camps, riding the wave of the Bring Your Own Device (BYOD) trend. And believe it or not, those workers want Windows tablets like the Surface more than they want iPads.Forrester also concludes that it’s probably curtains for BlackBerry, which the research house labels a “fading presence”.The strongest argument for the legitimacy of the data is the sample size of 9,766 information workers that Forrester polled. Typically, market research firms – whether asking questions about technology, political candidates or laundry soap – poll a representative group of respondents and try to extrapolate that data out to the entire population in question, usually Americans or even worldwide users. The larger the sample size, typically, the greater the reliability of the findings. The Rise and Rise of Mobile Payment Technology
Essential Reading! Get my 3rd book: Eat Their Lunch “The first ever playbook for B2B salespeople on how to win clients and customers who are already being serviced by your competition.” Buy Now Is what you are doing right now aligned with your mission and your purpose? Is it something that moves you closer to the ultimate outcomes you need to achieve? Or, is it something less than that?Is what you are doing important? Is it something that matters? Is it the proactive work that moves the needle on your overall results? If what you are doing isn’t going to make a difference were you not doing it, is it the best use of your time?The goals that you have written down require that certain actions be taken, in most cases, with a discipline that ensures they are achieved. Is what you are doing something that is so closely tied to those goals that anyone watching you right now would immediately understand what you are doing, why you are doing it, and what your long-term goal is? Or would they be confused by the incongruity of your written goals and your current actions?When you complete what you are doing right now, are you going to be proud of having done so? Will you point to what you are doing right now as an outcome that was worthy of your time and effort, assured that it made some contribution to the project or outcomes that are most important in your world?Should someone else really be doing what you are doing now? Does the task or the outcome belong to another person who is really charged with this responsibility? Would someone else create a far better outcome than you when they to do what you are doing now?Is what you are doing trivial or meaningless? Is it a distraction from what you should be doing? If you weren’t doing it right now, would you have time to do more important and more meaningful work? Is it stealing your time from more difficult, but more important work?In the future, will you wish that you hadn’t spent the time doing what you are doing right now because some other outcome could have been obtained?If you are grateful for the time you have, you will recognize how short that time is, and you will use it to do what’s important.